Publications

2023

Liposomal Therapy.
Albadawi, H., Mitragotri, S., & Oklu, R. (2023). Introduction to Cancer Biology 3, 436. 

Digital therapeutics in the clinic.
Phan, P., Mitragotri, S., & Zhao, Z. (2023). Bioengineering & Translational Medicine, e10536. https://doi.org/10.1002/btm2.10536

A backpack-based myeloid cell therapy for multiple sclerosis.
Kapate, N., Dunne, M., Kumbhojkar, N., Prakash, S., Wang, L.L.W., Graveline, A., … (2023). Proceedings of the National Academy of Sciences 120 (17), e2221535120. https://doi.org/10.1073/pnas.2221535120

A polymer‐based systemic hemostat for managing uncontrolled bleeding.
Gao, Y., Ikeda‐Imafuku, M., Zhao, Z., Joshi, M., & Mitragotri, S. (2023). Bioengineering & Translational Medicine, e10516. https://doi.org/10.1002/btm2.10516

Spotlight on Genetic Kidney Diseases: A Call for Drug Delivery and Nanomedicine Solutions.
Trac, N., Ashraf, A., Giblin, J., Prakash, S., Mitragotri, S., & Chung, E.J. (2023). ACS Nano 17 (7), 6165-6177. https://doi.org/10.1021/acsnano.2c12140

Nonspherical ultrasound microbubbles.
Dasgupta, A., Sun, T., Palomba, R., Rama, E., Zhang, Y., Power, C., Moeckel, D., … (2023). Proceedings of the National Academy of Sciences 120 (13), e2218847120. https://doi.org/10.1073/pnas.2218847120

Alzheimer's and Parkinson's disease therapies in the clinic.
Chopade, P., Chopade, N., Zhao, Z. M., Mitragotri, S., Liao, R., & Suja, V. C. (2023). Bioengineering & Translational Medicine, 8(1). https://doi.org/10.1002/btm2.10367

RNA therapeutics in the clinic.
Curreri, A., Sankholkar, D., Mitragotri, S., & Zhao, Z. (2023). Bioengineering & Translational Medicine, 8(1).  https://doi.org/10.1002/btm2.10374

Deep Eutectic Solvents for Subcutaneous Delivery of Protein Therapeutics.
Curreri, A.M., Kim, J., Dunne, M., Angsantikul, P., Goetz, M., Gao, Y., & Mitragotri, S. (2023). Advanced Science 10 (7), 2205389. https://doi.org/10.1002/advs.202205389

Engineering of bioactive nanocomplexes on dental floss for targeted gingival therapy.
Nakajima, M., Nakajima, N., Guo, J., & Mitragotri, S. (2023). Bioengineering & Translational Medicine 8 (2), e10452.  https://doi.org/10.1002/btm2.10452

Ultrasound‐mediated delivery of flexibility‐tunable polymer drug conjugates for treating glioblastoma.
Sun, T., Krishnan, V., Pan, D.C., Filippov, S.K., Ravid, S., Sarode, A., Kim, J., … (2023). Bioengineering & Translational Medicine 8 (2), e10408.  https://doi.org/10.1002/btm2.10408

Materials for Cell Surface Engineering.
Adebowale, K., Liao, R., Suja, V.C., Kapate, N., Lu, A., Gao, Y., & Mitragotri, S. (2023). Advanced Materials, 2210059. https://doi.org/10.1002/adma.202210059

Leadership transition.
Mitragotri, S. (2023). Bioengineering & Translational Medicine, 8(1). https://doi.org/10.1002/btm2.10422

2022

Extracellular matrix degrading enzyme with stroma-targeting peptides enhance the penetration of liposomes into tumors.
Ikeda-Imafuku, M., Gao, Y. S., Shaha, S., Wang, L. L. W., Park, K. S., Nakajima, M., Adebowale, O., & Mitragotri, S. (2022). Journal of Controlled Release, 352, 1093-1103. https://doi.org/10.1016/j.jconrel.2022.11.007

Modularity of RBC hitchhiking with polymeric nanoparticles: testing the limits of non-covalent adsorption.
Lenders, V., Escudero, R., Koutsoumpou, X., Alvarez, L. A., Rozenski, J., Soenen, S. J., Zhao, Z. M., Mitragotri, S., Baatsen, P., Allegaert, K., Toelen, J., & Manshian, B. B. (2022). Journal of Nanobiotechnology, 20(1). https://doi.org/10.1186/s12951-022-01544-0

Engineering of bioactive nanocomplexes on dental floss for targeted gingival therapy.
Nakajima, M., Nakajima, N., Guo, J. L., & Mitragotri, S. (2022). Bioengineering & Translational Medicine. https://doi.org/10.1002/btm2.10452

A Long-Lasting Skin Protectant Based on CG-101, a Deep Eutectic Solvent Comprising Choline and Geranic Acid.
Shevachman, M., Mandal, A., Gelston, K., Mitragotri, S., & Joshi, N. (2022). Global Challenges, 6(11). https://doi.org/10.1002/gch2.202200064

Ultrasound-mediated delivery of flexibility-tunable polymer drug conjugates for treating glioblastoma.
Sun, T., Krishnan, V., Pan, D. C., Filippov, S. K., Ravid, S., Sarode, A., Kim, J., Zhang, Y. Z., Power, C., Aday, S., Guo, J. L., Karp, J. M., McDannold, N. J., & Mitragotri, S. S. (2022). Bioengineering & Translational Medicine. https://doi.org/10.1002/btm2.10408

Red Blood Cell Anchoring Enables Targeted Transduction and Re-Administration of AAV-Mediated Gene Therapy.
Zhao, Z. M., Kim, J., Suja, V. C., Kapate, N., Gao, Y. S., Guo, J. L., Muzykantov, V. R., & Mitragotri, S. (2022). Advanced Science, 9(24). https://doi.org/10.1002/advs.202201293

Ionic Liquid-Mediated Transdermal Delivery of Thrombosis-Detecting Nanosensors.
Bekdemir, A., Tanner, E. E. L., Kirkpatrick, J., Soleimany, A. P., Mitragotri, S., & Bhatia, S. N. (2022). Adv Healthc Mater, e2102685. https://doi.org/10.1002/adhm.202102685

Particle Shape Engineering for Improving Safety and Efficacy of Doxorubicin - a Case Study of Rod-Shaped Carriers in Resistant Small Cell Lung Cancer.
Shukla, S. K., A. Sarode, X. Wang, S. Mitragotri, and V. Gupta. Biomater Adv 137 (Jun 2022): 212850. https://dx.doi.org/10.1016/j.bioadv.2022.212850.

Viral vector-based gene therapies in the clinic.
Zhao, Z.; Anselmo, A. C.; Mitragotri, S. Bioeng Transl Med 2022, 7 (1), e10258. https://doi.org//10.1002/btm2.10258

Imiquimod-gemcitabine nanoparticles harness immune cells to suppress breast cancer.
Singh, B.; Maharjan, S.; Pan, D. C.; Zhao, Z.; Gao, Y.; Zhang, Y. S.; Mitragotri, S. Biomaterials 2022, 280, 121302. https://doi.org//10.1016/j.biomaterials.2021.121302

Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Myerson, J. W.; Patel, P. N.; Rubey, K. M.; Zamora, M. E.; Zaleski, M. H.; Habibi, N.; Walsh, L. R.; Lee, Y. W.; Luther, D. C.; Ferguson, L. T.; et al. Nat Nanotechnol 2022, 17 (1), 86-97. https://doi.org//10.1038/s41565-021-00997-y

Hyaluronic Acid Nanoparticles for Immunogenic Chemotherapy of Leukemia and T-Cell Lymphoma.
Krishnan, V.; Dharamdasani, V.; Bakre, S.; Dhole, V.; Wu, D.; Budnik, B.; Mitragotri, S. Pharmaceutics 2022, 14 (2). https://doi.org//10.3390/pharmaceutics14020466

A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson's disease.
Kim, J.; Gao, Y.; Zhao, Z.; Rodrigues, D.; Tanner, E. E. L.; Ibsen, K.; Sasmal, P. K.; Jaladi, R.; Alikunju, S.; Mitragotri, S. Proc Natl Acad Sci U S A 2022, 119 (9). https://10.1073/pnas.2110450119

Differential Macrophage Responses to Gold Nanostars and Their Implication for Cancer Immunotherapy.
Kenry; Eschle, B. K.; Andreiuk, B.; Gokhale, P. C.; Mitragotri, S. Adv Ther-Germany 2022, 5 (3). https://10.1002/adtp.202100198.

Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
M Ikeda-Imafuku, LLW Wang, D Rodrigues, S Shaha et al. Journal of Controlled Release, 2022. https://doi.org/10.1016/j.jconrel.2022.03.043

Nanoparticle Properties Influence Transendothelial Migration of Monocytes.
Habibi, N.; Brown, T. D.; Adu-Berchie, K.; Christau, S.; Raymond, J. E.; Mooney, D. J.; Mitragotri, S.; Lahann, J. Langmuir 2022. https://10.1021/acs.langmuir.2c00200

Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long-term treatment of inflammatory arthritis.
Gao, Y.; Vogus, D.; Zhao, Z.; He, W.; Krishnan, V.; Kim, J.; Shi, Y.; Sarode, A.; Ukidve, A.; Mitragotri, S. Bioeng Transl Med 2022, 7 (1), e10245. https://doi.org//10.1002/btm2.10245

Dual Affinity to RBCs and Target Cells (DART) Enhances Both Organ-and Cell Type-Targeting of Intravascular Nanocarriers
Ferguson, L. T., Hood, E. D., Shuvaeva, T., Shuvaev, V. V., Basil, M. C., Wang, Z. C., Nong, J., Ma, X. N., Wu, J. C., Myerson, J. W., Marcos-Contreras, O. A., Katzen, J., Carl, J. M., Morrisey, E. E., Cantu, E., Villa, C. H., Mitragotri, S., Muzykantov, V. R., & Brenner, J. S. (2022). ACS Nano, 16(3), 4666-4683. https://doi.org/10.1021/acsnano.1c11374

Ionic Liquid‐Mediated Transdermal Delivery of Thrombosis‐Detecting Nanosensors
A Bekdemir, EEL Tanner, J Kirkpatrick, AP Soleimany… - Advanced Healthcare Materials, 2022. https://doi.org/10.1002/adhm.202102685

2021

Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases.
Zhao, Z.; Ukidve, A.; Krishnan, V.; Fehnel, A.; Pan, D. C.; Gao, Y.; Kim, J.; Evans, M. A.; Mandal, A.; Guo, J.; et al. Nat Biomed Eng 2021, 5 (5), 441-454. https://doi.org//10.1038/s41551-020-00644-2

Ionic Liquid-Enabled Topical Delivery of Immunomodulators.
Zhao, Z.; Tanner, E. E. L.; Kim, J.; Ibsen, K.; Gao, Y.; Mitragotri, S. ACS Biomater Sci Eng 2021, 7 (6), 2783-2790. https://doi.org//10.1021/acsbiomaterials.1c00322

Gemcitabine and doxorubicin in immunostimulatory monophosphoryl lipid A liposomes for treating breast cancer.
Wu, D.; Zhao, Z.; Kim, J.; Razmi, A.; Wang, L. L.; Kapate, N.; Gao, Y.; Peng, K.; Ukidve, A.; Mitragotri, S. Bioeng Transl Med 2021, 6 (1), e10188. https://doi.org//10.1002/btm2.10188

Optimized 5-Fluorouridine Prodrug for Co-Loading with Doxorubicin in Clinically Relevant Liposomes.
Wu, D.; Vogus, D.; Krishnan, V.; Broto, M.; Pusuluri, A.; Zhao, Z.; Kapate, N.; Mitragotri, S. Pharmaceutics 2021, 13 (1). https://doi.org//10.3390/pharmaceutics13010107

Cell therapies in the clinic.
Wang, L. L.; Janes, M. E.; Kumbhojkar, N.; Kapate, N.; Clegg, J. R.; Prakash, S.; Heavey, M. K.; Zhao, Z.; Anselmo, A. C.; Mitragotri, S. Bioeng Transl Med 2021, 6 (2), e10214. https://doi.org//10.1002/btm2.10214

The evolution of commercial drug delivery technologies.
Vargason, A. M.; Anselmo, A. C.; Mitragotri, S. Nat Biomed Eng 2021, 5 (9), 951-967. https://doi.org//10.1038/s41551-021-00698-w

Overcoming biological barriers to improve solid tumor immunotherapy.
Ukidve, A.; Cu, K.; Kumbhojkar, N.; Lahann, J.; Mitragotri, S. Drug Deliv Transl Res 2021, 11 (6), 2276-2301. https://doi.org//10.1007/s13346-021-00923-8

Bioinspired particle engineering for non-invasive inhaled drug delivery to the lungs.
Shukla, S. K.; Sarode, A.; Kanabar, D. D.; Muth, A.; Kunda, N. K.; Mitragotri, S.; Gupta, V. Mater Sci Eng C Mater Biol Appl 2021, 128, 112324. https://doi.org//10.1016/j.msec.2021.112324

Enhancement of Anticancer Efficacy and Tumor Penetration of Sorafenib by Ionic Liquids.
Shi, Y.; Zhao, Z.; Peng, K.; Gao, Y.; Wu, D.; Kim, J.; Mitragotri, S. Adv Healthc Mater 2021, 10 (2), e2001455. https://doi.org//10.1002/adhm.202001455

A dual macrophage polarizer conjugate for synergistic melanoma therapy.
Sallam, M. A.; Wyatt Shields Iv, C.; Prakash, S.; Kim, J.; Pan, D. C.; Mitragotri, S. J Control Release 2021, 335, 333-344. https://doi.org//10.1016/j.jconrel.2021.05.033

Formulation-based approaches for dermal delivery of vaccines and therapeutic nucleic acids: Recent advances and future perspectives.
Sallam, M. A.; Prakash, S.; Kumbhojkar, N.; Shields, C. W. t.; Mitragotri, S. Bioeng Transl Med 2021, 6 (3), e10215. https://doi.org//10.1002/btm2.10215

Modulation of Gastrointestinal Mucus Properties with Ionic Liquids for Drug Delivery.
Peng, K.; Gao, Y.; Angsantikul, P.; LaBarbiera, A.; Goetz, M.; Curreri, A. M.; Rodrigues, D.; Tanner, E. E. L.; Mitragotri, S. Adv Healthc Mater 2021, 10 (13), e2002192. https://doi.org//10.1002/adhm.202002192

Hyaluronic acid-doxorubicin nanoparticles for targeted treatment of colorectal cancer.
Pan, D. C.; Krishnan, V.; Salinas, A. K.; Kim, J.; Sun, T.; Ravid, S.; Peng, K.; Wu, D.; Nurunnabi, M.; Nelson, J. A.; et al. Bioeng Transl Med 2021, 6 (1), e10166. https://doi.org//10.1002/btm2.10166

Topical treatment of periodontitis using an iongel.
Nakajima, M.; Tanner, E. E. L.; Nakajima, N.; Ibsen, K. N.; Mitragotri, S. Biomaterials 2021, 276, 121069. https://doi.org//10.1016/j.biomaterials.2021.121069

Noninvasive Assessment of Epidermal Genomic Markers of UV Exposure in Skin.
Muradova, E.; Patel, N.; Sell, B.; Bittencourt, B. B.; Ojeda, S. S.; Adelmann, C. H.; Cen, L.; Cheng, C. H.; Shen, J.; Davis, C. M.; et al. J Invest Dermatol 2021, 141 (1), 124-131 e122. https://doi.org//10.1016/j.jid.2020.05.093

Enhancement of elastin expression by transdermal administration of sialidase isozyme Neu2.
Minami, A.; Fujita, Y.; Goto, J.; Iuchi, A.; Fujita, K.; Mikami, Y.; Shiratori, M.; Ishii, A.; Mitragotri, S.; Iwao, Y.; et al. Sci Rep 2021, 11 (1), 3302. https://doi.org//10.1038/s41598-021-82820-1

Hyaluronic acid conjugates for topical treatment of skin cancer lesions.
Krishnan, V.; Peng, K.; Sarode, A.; Prakash, S.; Zhao, Z.; Filippov, S. K.; Todorova, K.; Sell, B. R.; Lujano, O.; Bakre, S.; et al. Sci Adv 2021, 7 (24). https://doi.org//10.1126/sciadv.abe6627

Clinical translation of choline and geranic acid deep eutectic solvent.
Ko, J.; Mandal, A.; Dhawan, S.; Shevachman, M.; Mitragotri, S.; Joshi, N. Bioeng Transl Med 2021, 6 (2), e10191. https://doi.org//10.1002/btm2.10191

A Deep Eutectic Solvent-Based Approach to Intravenous Formulation.
Kim, J.; Shi, Y.; Kwon, C. J.; Gao, Y.; Mitragotri, S. Adv Healthc Mater 2021, 10 (18), e2100585. https://doi.org//10.1002/adhm.202100585

Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years.
Kapate, N.; Clegg, J. R.; Mitragotri, S. Adv Drug Deliv Rev 2021, 177, 113807. https://doi.org//10.1016/j.addr.2021.05.017

Red blood cells: The metamorphosis of a neglected carrier into the natural mothership for artificial nanocarriers.
Glassman, P. M.; Hood, E. D.; Ferguson, L. T.; Zhao, Z.; Siegel, D. L.; Mitragotri, S.; Brenner, J. S.; Muzykantov, V. R. Adv Drug Deliv Rev 2021, 178, 113992. https://doi.org//10.1016/j.addr.2021.113992

Covalently Crosslinked Hydrogels via Step-Growth Reactions: Crosslinking Chemistries, Polymers, and Clinical Impact.
Gao, Y.; Peng, K.; Mitragotri, S. Adv Mater 2021, 33 (25), e2006362. https://doi.org//10.1002/adma.202006362

Recent Advances in Ionic Liquids in Biomedicine.
Curreri, A. M.; Mitragotri, S.; Tanner, E. E. L. Adv Sci (Weinh) 2021, 8 (17), e2004819. https://doi.org//10.1002/advs.202004819

Red Blood Cell Hitchhiking: A Novel Approach for Vascular Delivery of Nanocarriers.
Brenner, J. S.; Mitragotri, S.; Muzykantov, V. R. Annu Rev Biomed Eng 2021, 23, 225-248. https://doi.org//10.1146/annurev-bioeng-121219-024239

Nanoparticles in the clinic: An update post COVID-19 vaccines.
Anselmo, A. C.; Mitragotri, S. Bioeng Transl Med 2021, e10246. https://doi.org//10.1002/btm2.10246

Ionic Liquids and Deep Eutectic Solvents for Enhanced Delivery of Antibodies in the Gastrointestinal Tract.
Angsantikul, P., Peng, K. V., Curreri, A. M., Chua, Y., Chen, K. V. Z., Ehondor, J., & Mitragotri, S. (2021). Advanced Functional Materials, 31(44). https://doi.org/10.1002/adfm.202002912

Percutaneous liquid ablation agent for tumor treatment and drug delivery.
Albadawi, H.; Zhang, Z.; Altun, I.; Hu, J.; Jamal, L.; Ibsen, K. N.; Tanner, E. E. L.; Mitragotri, S.; Oklu, R. Sci Transl Med 2021, 13 (580). https://doi.org//10.1126/scitranslmed.abe3889

Targeting Strategies for Tissue-Specific Drug Delivery.
Zhao, Z.; Ukidve, A.; Kim, J.; Mitragotri, S. Cell 2020, 181 (1), 151-167. https://doi.org//10.1016/j.cell.2020.02.001

Engineering of Living Cells with Polyphenol-Functionalized Biologically Active Nanocomplexes.
Zhao, Z.; Pan, D. C.; Qi, Q. M.; Kim, J.; Kapate, N.; Sun, T.; Shields, C. W. t.; Wang, L. L.; Wu, D.; Kwon, C. J.; et al. Adv Mater 2020, 32 (49), e2003492. https://doi.org//10.1002/adma.202003492

Topical Application of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells in Combination with Sponge Spicules for Treatment of Photoaging.
Zhang, K.; Yu, L.; Li, F. R.; Li, X.; Wang, Z.; Zou, X.; Zhang, C.; Lv, K.; Zhou, B.; Mitragotri, S.; et al. Int J Nanomedicine 2020, 15, 2859-2872. https://doi.org//10.2147/IJN.S249751

Design principles of drug combinations for chemotherapy.
Wu, D.; Pusuluri, A.; Vogus, D.; Krishnan, V.; Shields, C. W. t.; Kim, J.; Razmi, A.; Mitragotri, S. J Control Release 2020, 323, 36-46. https://doi.org//10.1016/j.jconrel.2020.04.018

Development of inhalable quinacrine loaded bovine serum albumin modified cationic nanoparticles: Repurposing quinacrine for lung cancer therapeutics.
Vaidya, B.; Kulkarni, N. S.; Shukla, S. K.; Parvathaneni, V.; Chauhan, G.; Damon, J. K.; Sarode, A.; Garcia, J. V.; Kunda, N.; Mitragotri, S.; et al. Int J Pharm 2020, 577, 118995. https://doi.org//10.1016/j.ijpharm.2019.118995

Ionic liquid-mediated delivery of insulin to buccal mucosa.
Vaidya, A.; Mitragotri, S. J Control Release 2020, 327, 26-34. https://doi.org//10.1016/j.jconrel.2020.07.037

Erythrocyte-driven immunization via biomimicry of their natural antigen-presenting function.
Ukidve, A.; Zhao, Z.; Fehnel, A.; Krishnan, V.; Pan, D. C.; Gao, Y.; Mandal, A.; Muzykantov, V.; Mitragotri, S. Proc Natl Acad Sci U S A 2020, 117 (30), 17727-17736. https://doi.org//10.1073/pnas.2002880117

Ionic-Liquid-Based Safe Adjuvants.
Ukidve, A.; Cu, K.; Goetz, M.; Angsantikul, P.; Curreri, A.; Tanner, E. E. L.; Lahann, J.; Mitragotri, S. Adv Mater 2020, 32 (46), e2002990. https://doi.org//10.1002/adma.202002990

Stabilization and Topical Skin Delivery of Framework Nucleic Acids using Ionic Liquids.
Tanner, E. E. L.; Wiraja, C.; Curreri, C. A.; Xu, C. J.; Mitragotri, S. Adv Ther-Germany 2020, 3 (7). https://doi.org/10.1002/adtp.202000041

Physical triggering strategies for drug delivery.
Sun, T.; Dasgupta, A.; Zhao, Z.; Nurunnabi, M.; Mitragotri, S. Adv Drug Deliv Rev 2020, 158, 36-62. https://doi.org//10.1016/j.addr.2020.06.010

Harnessing cells to deliver nanoparticle drugs to treat cancer.
Singh, B.; Mitragotri, S. Biotechnol Adv 2020, 42, 107339. https://doi.org//10.1016/j.biotechadv.2019.01.006

Materials for Immunotherapy.
Shields, C. W. t.; Wang, L. L.; Evans, M. A.; Mitragotri, S. Adv Mater 2020, 32 (13), e1901633. https://doi.org//10.1002/adma.201901633

Cellular backpacks for macrophage immunotherapy.
Shields, C. W. t.; Evans, M. A.; Wang, L. L.; Baugh, N.; Iyer, S.; Wu, D.; Zhao, Z.; Pusuluri, A.; Ukidve, A.; Pan, D. C.; et al. Sci Adv 2020, 6 (18), eaaz6579. https://doi.org//10.1126/sciadv.aaz6579

Oral delivery of sorafenib through spontaneous formation of ionic liquid nanocomplexes.
Shi, Y.; Zhao, Z.; Gao, Y.; Pan, D. C.; Salinas, A. K.; Tanner, E. E. L.; Guo, J.; Mitragotri, S. J Control Release 2020, 322, 602-609. https://doi.org//10.1016/j.jconrel.2020.03.018

Layered self-assemblies for controlled drug delivery: A translational overview.
Sarode, A.; Annapragada, A.; Guo, J.; Mitragotri, S. Biomaterials 2020, 242, 119929. https://doi.org//10.1016/j.biomaterials.2020.119929

Hyaluronic Acid Conjugates of Vorinostat and Bexarotene for Treatment of Cutaneous Malignancies.
Sallam, M. A., Prakash, S., Krishnan, V., Todorova, K., Mandinova, A., & Mitragotri, S. (2020). Advanced Therapeutics, 3(10). https://doi.org/10.1002/adtp.202000116

Multifunctional Synthetic Protein Nanoparticles via Reactive Electrojetting.
Quevedo, D. F.; Habibi, N.; Gregory, J. V.; Hernandez, Y.; Brown, T. D.; Miki, R.; Plummer, B. N.; Rahmani, S.; Raymond, J. E.; Mitragotri, S.; et al. Macromol Rapid Commun 2020, 41 (23), e2000425. https://doi.org//10.1002/marc.202000425

Reply to Peiretti et al.: Effect of CAGE on fat uptake and food intake.
Nurunnabi, M.; Ibsen, K. N.; Tanner, E. E. L.; Mitragotri, S. Proc Natl Acad Sci U S A 2020, 117 (15), 8249. https://doi.org//10.1073/pnas.2001030117

Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow.
Nowak, M.; Brown, T. D.; Graham, A.; Helgeson, M. E.; Mitragotri, S. Bioeng Transl Med 2020, 5 (2), e10153. https://doi.org//10.1002/btm2.10153

The Future is Bright.
Mitragotri, S.; Anselmo, A. C. BioTM Buzz (Volume 5, Issue 3): Bioeng Transl Med 2020, 5 (3), e10185. https://doi.org//10.1002/btm2.10185

Year 2020 in review.
Mitragotri, S. Bioengineering & Translational Medicine: Bioeng Transl Med 2020, 5 (3), e10178. https://doi.org//10.1002/btm2.10178

Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations.
Mandal, A.; Kumbhojkar, N.; Reilly, C.; Dharamdasani, V.; Ukidve, A.; Ingber, D. E.; Mitragotri, S. Sci Adv 2020, 6 (30), eabb6049. https://doi.org//10.1126/sciadv.abb6049

Hydrogels in the clinic.
Mandal, A.; Clegg, J. R.; Anselmo, A. C.; Mitragotri, S. Bioeng Transl Med 2020, 5 (2), e10158. https://doi.org//10.1002/btm2.10158

Coupled influences of particle shape, surface property and flow hydrodynamics on rod-shaped colloid transport in porous media.
Ma, H.; Bolster, C.; Johnson, W. P.; Li, K.; Pazmino, E.; Camacho, K. M.; Anselmo, A. C.; Mitragotri, S. J Colloid Interface Sci 2020, 577, 471-480. https://doi.org//10.1016/j.jcis.2020.05.022

Correlations Between Skin Barrier Integrity and Delivery of Hydrophilic Molecules in the Presence of Penetration Enhancers.
Lin, X.; Wang, Z.; Ou, H.; Mitragotri, S.; Chen, M. Pharm Res 2020, 37 (6), 100. https://doi.org//10.1007/s11095-020-02800-4

Skin Delivery of siRNA Using Sponge Spicules in Combination with Cationic Flexible Liposomes.
Liang, X.; Zhang, J.; Ou, H.; Chen, J.; Mitragotri, S.; Chen, M. Mol Ther Nucleic Acids 2020, 20, 639-648. https://doi.org//10.1016/j.omtn.2020.04.003

Nanoparticles for topical drug delivery: Potential for skin cancer treatment.
Krishnan, V.; Mitragotri, S. Adv Drug Deliv Rev 2020, 153, 87-108. https://doi.org//10.1016/j.addr.2020.05.011

The Search for Antifungal Prophylaxis After Artificial Corneal Surgery-An In Vitro Study.
Kim, S.; Bispo, P. J. M.; Tanner, E. E. L.; Mitragotri, S.; RN, E. S.; Gipson, I.; Chodosh, J.; Behlau, I.; Paschalis, E. I.; Gilmore, M. S.; et al. Cornea 2020, 39 (12), 1547-1555. https://doi.org//10.1097/ICO.0000000000002433

Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases.
He, W.; Kapate, N.; Shields, C. W. t.; Mitragotri, S. Adv Drug Deliv Rev 2020, 165-166, 15-40. https://doi.org//10.1016/j.addr.2019.12.001

Author Correction: Transdermal delivery of nobiletin using ionic liquids.
Hattori, T.; Tagawa, H.; Inai, M.; Kan, T.; Kimura, S. I.; Itai, S.; Mitragotri, S.; Iwao, Y. Sci Rep 2020, 10 (1), 3967. https://doi.org//10.1038/s41598-020-60921-7

Protein-avoidant ionic liquid (PAIL)-coated nanoparticles to increase bloodstream circulation and drive biodistribution.
Hamadani, C. M.; Goetz, M. J.; Mitragotri, S.; Tanner, E. E. L. Sci Adv 2020, 6 (48). https://doi.org//10.1126/sciadv.abd7563

Molecular mechanism of the skin permeation enhancing effect of ethanol: a molecular dynamics study.
Gupta, R.; Badhe, Y.; Rai, B.; Mitragotri, S. RSC Adv 2020, 10 (21), 12234-12248. https://doi.org//10.1039/d0ra01692f

Permeation of nanoparticles across the intestinal lipid membrane: dependence on shape and surface chemistry studied through molecular simulations.
Gupta, R.; Badhe, Y.; Mitragotri, S.; Rai, B. Nanoscale 2020, 12 (11), 6318-6333. https://doi.org//10.1039/c9nr09947f

Programmable Delivery of Synergistic Cancer Drug Combinations Using Bicompartmental Nanoparticles.
Gregory, J. V.; Vogus, D. R.; Barajas, A.; Cadena, M. A.; Mitragotri, S.; Lahann, J. Adv Healthc Mater 2020, 9 (21), e2000564. https://doi.org//10.1002/adhm.202000564

Vascular Drug Delivery Using Carrier Red Blood Cells: Focus on RBC Surface Loading and Pharmacokinetics.
Glassman, P. M.; Villa, C. H.; Ukidve, A.; Zhao, Z.; Smith, P.; Mitragotri, S.; Russell, A. J.; Brenner, J. S.; Muzykantov, V. R. Pharmaceutics 2020, 12 (5). https://doi.org//10.3390/pharmaceutics12050440

A polymer-based systemic hemostatic agent.
Gao, Y.; Sarode, A.; Kokoroskos, N.; Ukidve, A.; Zhao, Z.; Guo, S.; Flaumenhaft, R.; Gupta, A. S.; Saillant, N.; Mitragotri, S. Sci Adv 2020, 6 (31), eaba0588. https://doi.org//10.1126/sciadv.aba0588

Investigating the potential use of an ionic liquid (1-Butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide) as an anti-fungal treatment against the amphibian chytrid fungus, Batrachochytrium dendrobatidis.
DiRenzo, G. V.; Chen, R.; Ibsen, K.; Toothman, M.; Miller, A. J.; Gershman, A.; Mitragotri, S.; Briggs, C. J. PLoS One 2020, 15 (4), e0231811. https://doi.org//10.1371/journal.pone.0231811

Topical delivery of siRNA into skin using ionic liquids.
Dharamdasani, V.; Mandal, A.; Qi, Q. M.; Suzuki, I.; Bentley, M.; Mitragotri, S. J Control Release 2020, 323, 475-482. https://doi.org//10.1016/j.jconrel.2020.04.038

Delivery Strategies for Skin: Comparison of Nanoliter Jets, Needles and Topical Solutions.
Cu, K.; Bansal, R.; Mitragotri, S.; Fernandez Rivas, D. Ann Biomed Eng 2020, 48 (7), 2028-2039. https://doi.org//10.1007/s10439-019-02383-1

Effect of Nanoparticle Composition, Size, Shape, and Stiffness on Penetration Across the Blood-Brain Barrier.
Brown, T. D.; Habibi, N.; Wu, D.; Lahann, J.; Mitragotri, S. ACS Biomater Sci Eng 2020, 6 (9), 4916-4928. https://doi.org//10.1021/acsbiomaterials.0c00743

Amphiphilic Polyacrylamide Excipients Lead to a Record-Breaking Fast-Acting Insulin.
Angsantikul, P.; Mitragotri, S. Trends Pharmacol Sci 2020, 41 (10), 681-684. https://doi.org//10.1016/j.tips.2020.08.006

Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers.
Zhao, Z.; Ukidve, A.; Krishnan, V.; Mitragotri, S. Adv Drug Deliv Rev 2019, 143, 3-21. https://doi.org//10.1016/j.addr.2019.01.002

Erythrocyte leveraged chemotherapy (ELeCt): Nanoparticle assembly on erythrocyte surface to combat lung metastasis.
Zhao, Z.; Ukidve, A.; Gao, Y.; Kim, J.; Mitragotri, S. Sci Adv 2019, 5 (11), eaax9250. https://doi.org//10.1126/sciadv.aax9250

Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes.
Zhang, C.; Zhang, K.; Zhang, J.; Ou, H.; Duan, J.; Zhang, S.; Wang, D.; Mitragotri, S.; Chen, M. Biomater Sci 2019, 7 (4), 1299-1310. https://doi.org//10.1039/c8bm01555d

Cyclodextrin modified erlotinib loaded PLGA nanoparticles for improved therapeutic efficacy against non-small cell lung cancer.
Vaidya, B.; Parvathaneni, V.; Kulkarni, N. S.; Shukla, S. K.; Damon, J. K.; Sarode, A.; Kanabar, D.; Garcia, J. V.; Mitragotri, S.; Muth, A.; et al. Int J Biol Macromol 2019, 122, 338-347. https://doi.org//10.1016/j.ijbiomac.2018.10.181

The Influence of Water on Choline-Based Ionic Liquids.
Tanner, E. E. L.; Piston, K. M.; Ma, H.; Ibsen, K. N.; Nangia, S.; Mitragotri, S. ACS Biomater Sci Eng 2019, 5 (7), 3645-3653. https://doi.org//10.1021/acsbiomaterials.9b00243

Design Principles of Ionic Liquids for Transdermal Drug Delivery.
Tanner, E. E. L.; Curreri, A. M.; Balkaran, J. P. R.; Selig-Wober, N. C.; Yang, A. B.; Kendig, C.; Fluhr, M. P.; Kim, N.; Mitragotri, S. Adv Mater 2019, 31 (27), e1901103. https://doi.org//10.1002/adma.201901103

Mechanistic study of transdermal delivery of macromolecules assisted by ionic liquids.
Qi, Q. M.; Mitragotri, S. J Control Release 2019, 311-312, 162-169. https://doi.org//10.1016/j.jconrel.2019.08.029

Immunological consequences of chemotherapy: Single drugs, combination therapies and nanoparticle-based treatments.
Pusuluri, A.; Wu, D.; Mitragotri, S. J Control Release 2019, 305, 130-154. https://doi.org//10.1016/j.jconrel.2019.04.020

Role of synergy and immunostimulation in design of chemotherapy combinations: An analysis of doxorubicin and camptothecin.
Pusuluri, A.; Krishnan, V.; Wu, D.; Shields, C. W. t.; Wang, L. W.; Mitragotri, S. Bioeng Transl Med 2019, 4 (2), e10129. https://doi.org//10.1002/btm2.10129

Treating Tumors at Low Drug Doses Using an Aptamer-Peptide Synergistic Drug Conjugate.
Pusuluri, A.; Krishnan, V.; Lensch, V.; Sarode, A.; Bunyan, E.; Vogus, D. R.; Menegatti, S.; Soh, H. T.; Mitragotri, S. Angew Chem Int Ed Engl 2019, 58 (5), 1437-1441. https://doi.org//10.1002/anie.201812650

Oral ionic liquid for the treatment of diet-induced obesity.
Nurunnabi, M.; Ibsen, K. N.; Tanner, E. E. L.; Mitragotri, S. Proc Natl Acad Sci U S A 2019, 116 (50), 25042-25047. https://doi.org//10.1073/pnas.1914426116

Editorial: The launch phase of Bioengineering & Translational Medicine.
Mitragotri, S. Bioeng Transl Med 2019, 4 (3), e10140. https://doi.org//10.1002/btm2.10140

Shape-based separation of synthetic microparticles.
Mage, P. L.; Csordas, A. T.; Brown, T.; Klinger, D.; Eisenstein, M.; Mitragotri, S.; Hawker, C.; Soh, H. T. Nat Mater 2019, 18 (1), 82-89. https://doi.org//10.1038/s41563-018-0244-9

On the issue of transparency and reproducibility in nanomedicine.
Leong, H. S.; Butler, K. S.; Brinker, C. J.; Azzawi, M.; Conlan, S.; Dufes, C.; Owen, A.; Rannard, S.; Scott, C.; Chen, C.; et al. Nat Nanotechnol 2019, 14 (7), 629-635. https://doi.org//10.1038/s41565-019-0496-9

Publisher Correction: On the issue of transparency and reproducibility in nanomedicine.
Leong, H. S.; Butler, K. S.; Brinker, C. J.; Azzawi, M.; Conlan, S.; Dufes, C.; Owen, A.; Rannard, S.; Scott, C.; Chen, C.; et al. Nat Nanotechnol 2019, 14 (8), 811. https://doi.org//10.1038/s41565-019-0523-x

Nanocrystals: A perspective on translational research and clinical studies.
Jarvis, M.; Krishnan, V.; Mitragotri, S. Bioeng Transl Med 2019, 4 (1), 5-16. https://doi.org//10.1002/btm2.10122

Transdermal delivery of nobiletin using ionic liquids.
Hattori, T.; Tagawa, H.; Inai, M.; Kan, T.; Kimura, S. I.; Itai, S.; Mitragotri, S.; Iwao, Y. Sci Rep 2019, 9 (1), 20191. https://doi.org//10.1038/s41598-019-56731-1

Effect of Chemical Permeation Enhancers on Skin Permeability: In silico screening using Molecular Dynamics simulations.
Gupta, R.; Dwadasi, B. S.; Rai, B.; Mitragotri, S. Sci Rep 2019, 9 (1), 1456. https://doi.org//10.1038/s41598-018-37900-0

Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions.
Da Silva-Candal, A.; Brown, T.; Krishnan, V.; Lopez-Loureiro, I.; Avila-Gomez, P.; Pusuluri, A.; Perez-Diaz, A.; Correa-Paz, C.; Hervella, P.; Castillo, J.; et al. J Control Release 2019, 309, 94-105. https://doi.org//10.1016/j.jconrel.2019.07.026

A microfluidic model of human brain (muHuB) for assessment of blood brain barrier.
Brown, T. D.; Nowak, M.; Bayles, A. V.; Prabhakarpandian, B.; Karande, P.; Lahann, J.; Helgeson, M. E.; Mitragotri, S. Bioeng Transl Med 2019, 4 (2), e10126. https://doi.org//10.1002/btm2.10126

Intestinal iontophoresis from mucoadhesive patches: a strategy for oral delivery.
Banerjee, A.; Chen, R.; Arafin, S.; Mitragotri, S. J Control Release 2019, 297, 71-78. https://doi.org//10.1016/j.jconrel.2019.01.037

Nanoparticles in the clinic: An update.
Anselmo, A. C.; Mitragotri, S. Bioeng Transl Med 2019, 4 (3), e10143. https://doi.org//10.1002/btm2.10143

Non-invasive delivery strategies for biologics.
Anselmo, A. C.; Gokarn, Y.; Mitragotri, S. Nat Rev Drug Discov 2019, 18 (1), 19-40. https://doi.org//10.1038/nrd.2018.183

Transdermal immunomodulation: Principles, advances and perspectives.
Zhao, Z.; Ukidve, A.; Dasgupta, A.; Mitragotri, S. Adv Drug Deliv Rev 2018, 127, 3-19. https://doi.org//10.1016/j.addr.2018.03.010

Controlling Complex Nanoemulsion Morphology Using Asymmetric Cosurfactants for the Preparation of Polymer Nanocapsules.
Zhang, M.; Corona, P. T.; Ruocco, N.; Alvarez, D.; Malo de Molina, P.; Mitragotri, S.; Helgeson, M. E. Langmuir 2018, 34 (3), 978-990. https://doi.org//10.1021/acs.langmuir.7b02843

Schedule dependent synergy of gemcitabine and doxorubicin: Improvement of in vitro efficacy and lack of in vitro-in vivo correlation.
Vogus, D. R.; Pusuluri, A.; Chen, R.; Mitragotri, S. Bioeng Transl Med 2018, 3 (1), 49-57. https://doi.org//10.1002/btm2.10082

Transdermal insulin delivery using choline-based ionic liquids (CAGE).
Tanner, E. E. L.; Ibsen, K. N.; Mitragotri, S. J Control Release 2018, 286, 137-144. https://doi.org//10.1016/j.jconrel.2018.07.029

Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells.
Pan, D. C.; Myerson, J. W.; Brenner, J. S.; Patel, P. N.; Anselmo, A. C.; Mitragotri, S.; Muzykantov, V. Sci Rep 2018, 8 (1), 1615. https://doi.org//10.1038/s41598-018-19897-8

Engineering clinical translation-Introduction to Special Issue Dedicated to 2017 Bioengineering and Translational Medicine Conference.
Kannan, R. M.; Mitragotri, S. Bioeng Transl Med 2018, 3 (2), 73. https://doi.org//10.1002/btm2.10099

Engineering clinical translation-Introduction to Special Issue Dedicated to 2017 Bioengineering and Translational Medicine Conference.
Kannan, R. M.; Mitragotri, S. Bioeng Transl Med 2018, 3 (3), 185. https://doi.org//10.1002/btm2.10115

Detachment of ligands from nanoparticle surface under flow and endothelial cell contact: Assessment using microfluidic devices.
Jarvis, M.; Arnold, M.; Ott, J.; Krishnan, V.; Pant, K.; Prabhakarpandian, B.; Mitragotri, S. Bioeng Transl Med 2018, 3 (2), 148-155. https://doi.org//10.1002/btm2.10089

Mechanism of Antibacterial Activity of Choline-Based Ionic Liquids (CAGE).
Ibsen, K. N.; Ma, H.; Banerjee, A.; Tanner, E. E. L.; Nangia, S.; Mitragotri, S. ACS Biomater Sci Eng 2018, 4 (7), 2370-2379. https://doi.org//10.1021/acsbiomaterials.8b00486

Macrophage-mediated delivery of light activated nitric oxide prodrugs with spatial, temporal and concentration control.
Evans, M. A.; Huang, P. J.; Iwamoto, Y.; Ibsen, K. N.; Chan, E. M.; Hitomi, Y.; Ford, P. C.; Mitragotri, S. Chem Sci 2018, 9 (15), 3729-3741. https://doi.org//10.1039/c8sc00015h

Influence of particle size and shape on their margination and wall-adhesion: implications in drug delivery vehicle design across nano-to-micro scale.
Cooley, M.; Sarode, A.; Hoore, M.; Fedosov, D. A.; Mitragotri, S.; Sen Gupta, A. Nanoscale 2018, 10 (32), 15350-15364. https://doi.org//10.1039/c8nr04042g

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude.
Brenner, J. S.; Pan, D. C.; Myerson, J. W.; Marcos-Contreras, O. A.; Villa, C. H.; Patel, P.; Hekierski, H.; Chatterjee, S.; Tao, J. Q.; Parhiz, H.; et al. Nat Commun 2018, 9 (1), 2684. https://doi.org//10.1038/s41467-018-05079-7

Ionic liquids for oral insulin delivery.
Banerjee, A.; Ibsen, K.; Brown, T.; Chen, R.; Agatemor, C.; Mitragotri, S. Proc Natl Acad Sci U S A 2018, 115 (28), 7296-7301. https://doi.org//10.1073/pnas.1722338115

Reply to Rogers and Gurau: Definitions of ionic liquids and deep eutectic solvents.
Banerjee, A.; Ibsen, K.; Brown, T.; Chen, R.; Agatemor, C.; Mitragotri, S. Proc Natl Acad Sci U S A 2018, 115 (47), E11000-E11001. https://doi.org//10.1073/pnas.1815526115

Ionic liquids for addressing unmet needs in healthcare.
Agatemor, C.; Ibsen, K. N.; Tanner, E. E. L.; Mitragotri, S. Bioeng Transl Med 2018, 3 (1), 7-25. https://doi.org//10.1002/btm2.10083

Skin Delivery of Hydrophilic Biomacromolecules Using Marine Sponge Spicules.
Zhang, S.; Ou, H.; Liu, C.; Zhang, Y.; Mitragotri, S.; Wang, D.; Chen, M. Mol Pharm 2017, 14 (9), 3188-3200. https://doi.org//10.1021/acs.molpharmaceut.7b00468

Synthesis of Oil-Laden Poly(ethylene glycol) Diacrylate Hydrogel Nanocapsules from Double Nanoemulsions.
Zhang, M.; Nowak, M.; Malo de Molina, P.; Abramovitch, M.; Santizo, K.; Mitragotri, S.; Helgeson, M. E. Langmuir 2017, 33 (24), 6116-6126. https://doi.org//10.1021/acs.langmuir.7b01162

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes.
Wibroe, P. P.; Anselmo, A. C.; Nilsson, P. H.; Sarode, A.; Gupta, V.; Urbanics, R.; Szebeni, J.; Hunter, A. C.; Mitragotri, S.; Mollnes, T. E.; et al. Nat Nanotechnol 2017, 12 (6), 589-594. https://doi.org//10.1038/nnano.2017.47

A hyaluronic acid conjugate engineered to synergistically and sequentially deliver gemcitabine and doxorubicin to treat triple negative breast cancer.
Vogus, D. R.; Evans, M. A.; Pusuluri, A.; Barajas, A.; Zhang, M.; Krishnan, V.; Nowak, M.; Menegatti, S.; Helgeson, M. E.; Squires, T. M.; et al. J Control Release 2017, 267, 191-202. https://doi.org//10.1016/j.jconrel.2017.08.016

Introduction to Special Issue: 2016 Translational Medicine and Bioengineering Conference.
Rege, K.; Mitragotri, S. Bioeng Transl Med 2017, 2 (2), 137-138. https://doi.org//10.1002/btm2.10071

Engineering live cell surfaces with functional polymers via cytocompatible controlled radical polymerization.
Niu, J.; Lunn, D. J.; Pusuluri, A.; Yoo, J. I.; O'Malley, M. A.; Mitragotri, S.; Soh, H. T.; Hawker, C. J. Nat Chem 2017, 9 (6), 537-545. https://doi.org//10.1038/nchem.2713

Drug Delivery Research for the Future: Expanding the Nano Horizons and Beyond.
Mitragotri, S.; Lammers, T.; Bae, Y. H.; Schwendeman, S.; De Smedt, S.; Leroux, J. C.; Peer, D.; Kwon, I. C.; Harashima, H.; Kikuchi, A.; et al. J Control Release 2017, 246, 183-184. https://doi.org//10.1016/j.jconrel.2017.01.011

Influence of Particle Geometry on Gastrointestinal Transit and Absorption following Oral Administration.
Li, D.; Zhuang, J.; He, H.; Jiang, S.; Banerjee, A.; Lu, Y.; Wu, W.; Mitragotri, S.; Gan, L.; Qi, J. ACS Appl Mater Interfaces 2017, 9 (49), 42492-42502. https://doi.org//10.1021/acsami.7b11821

Microfluidic co-culture devices to assess penetration of nanoparticles into cancer cell mass.
Jarvis, M.; Arnold, M.; Ott, J.; Pant, K.; Prabhakarpandian, B.; Mitragotri, S. Bioeng Transl Med 2017, 2 (3), 268-277. https://doi.org//10.1002/btm2.10079

Intestinal micropatches for oral insulin delivery.
Banerjee, A.; Wong, J.; Gogoi, R.; Brown, T.; Mitragotri, S. J Drug Target 2017, 25 (7), 608-615. https://doi.org//10.1080/1061186X.2017.1300664

Intestinal patch systems for oral drug delivery.
Banerjee, A.; Mitragotri, S. Curr Opin Pharmacol 2017, 36, 58-65. https://doi.org//10.1016/j.coph.2017.08.005

Transdermal Protein Delivery Using Choline and Geranate (CAGE) Deep Eutectic Solvent.
Banerjee, A.; Ibsen, K.; Iwao, Y.; Zakrewsky, M.; Mitragotri, S. Adv Healthc Mater 2017, 6 (15). https://doi.org//10.1002/adhm.201601411

Impact of particle elasticity on particle-based drug delivery systems.
Anselmo, A. C.; Mitragotri, S. Adv Drug Deliv Rev 2017, 108, 51-67. https://doi.org//10.1016/j.addr.2016.01.007

Therapeutic RNAi robed with ionic liquid moieties as a simple, scalable prodrug platform for treating skin disease.
Zakrewsky, M.; Mitragotri, S. J Control Release 2016, 242, 80-88. https://doi.org//10.1016/j.jconrel.2016.09.003

Choline and Geranate Deep Eutectic Solvent as a Broad-Spectrum Antiseptic Agent for Preventive and Therapeutic Applications.
Zakrewsky, M.; Banerjee, A.; Apte, S.; Kern, T. L.; Jones, M. R.; Sesto, R. E.; Koppisch, A. T.; Fox, D. T.; Mitragotri, S. Adv Healthc Mater 2016, 5 (11), 1282-1289. https://doi.org//10.1002/adhm.201600086

Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems.
Villa, C. H.; Anselmo, A. C.; Mitragotri, S.; Muzykantov, V. Adv Drug Deliv Rev 2016, 106 (Pt A), 88-103. https://doi.org//10.1016/j.addr.2016.02.007

The Effect of Polymeric Nanoparticles on Biocompatibility of Carrier Red Blood Cells.
Pan, D.; Vargas-Morales, O.; Zern, B.; Anselmo, A. C.; Gupta, V.; Zakrewsky, M.; Mitragotri, S.; Muzykantov, V. PLoS One 2016, 11 (3), e0152074. https://doi.org//10.1371/journal.pone.0152074

Non-affinity factors modulating vascular targeting of nano- and microcarriers.
Myerson, J. W.; Anselmo, A. C.; Liu, Y.; Mitragotri, S.; Eckmann, D. M.; Muzykantov, V. R. Adv Drug Deliv Rev 2016, 99 (Pt A), 97-112. https://doi.org//10.1016/j.addr.2015.10.011

De Novo Design of Skin-Penetrating Peptides for Enhanced Transdermal Delivery of Peptide Drugs.
Menegatti, S.; Zakrewsky, M.; Kumar, S.; De Oliveira, J. S.; Muraski, J. A.; Mitragotri, S. Adv Healthc Mater 2016, 5 (5), 602-609. https://doi.org//10.1002/adhm.201500634

Delivery of Exenatide and Insulin Using Mucoadhesive Intestinal Devices.
Gupta, V.; Hwang, B. H.; Doshi, N.; Banerjee, A.; Anselmo, A. C.; Mitragotri, S. Ann Biomed Eng 2016, 44 (6), 1993-2007. https://doi.org//10.1007/s10439-016-1558-x

DAFODIL: A novel liposome-encapsulated synergistic combination of doxorubicin and 5FU for low dose chemotherapy.
Camacho, K. M.; Menegatti, S.; Vogus, D. R.; Pusuluri, A.; Fuchs, Z.; Jarvis, M.; Zakrewsky, M.; Evans, M. A.; Chen, R.; Mitragotri, S. J Control Release 2016, 229, 154-162. https://doi.org//10.1016/j.jconrel.2016.03.027

Low-molecular-weight polymer-drug conjugates for synergistic anticancer activity of camptothecin and doxorubicin combinations.
Camacho, K. M.; Menegatti, S.; Mitragotri, S. Nanomedicine (Lond) 2016, 11 (9), 1139-1151. https://doi.org//10.2217/nnm.16.33

Role of nanoparticle size, shape and surface chemistry in oral drug delivery.
Banerjee, A.; Qi, J.; Gogoi, R.; Wong, J.; Mitragotri, S. J Control Release 2016, 238, 176-185. https://doi.org//10.1016/j.jconrel.2016.07.051

Intestinal mucoadhesive devices for oral delivery of insulin.
Banerjee, A.; Lee, J.; Mitragotri, S. Bioeng Transl Med 2016, 1 (3), 338-346. https://doi.org//10.1002/btm2.10015

Nanoparticles in the clinic.
Anselmo, A. C.; Mitragotri, S. Bioeng Transl Med 2016, 1 (1), 10-29. https://doi.org//10.1002/btm2.10003

Nucleic acid delivery into skin for the treatment of skin disease: Proofs-of-concept, potential impact, and remaining challenges.
Zakrewsky, M.; Kumar, S.; Mitragotri, S. J Control Release 2015, 219, 445-456. https://doi.org//10.1016/j.jconrel.2015.09.017

Ultrasonic delivery of silica-gold nanoshells for photothermolysis of sebaceous glands in humans: Nanotechnology from the bench to clinic.
Paithankar, D.; Hwang, B. H.; Munavalli, G.; Kauvar, A.; Lloyd, J.; Blomgren, R.; Faupel, L.; Meyer, T.; Mitragotri, S. J Control Release 2015, 206, 30-36. https://doi.org//10.1016/j.jconrel.2015.03.004

Journal of Drug Targeting Life Time Achievement Award for Prof. Robert Langer.
Mitragotri, S.; Hanes, J. J Drug Target 2015, 23 (7-8), 579. https://doi.org//10.3109/1061186X.2015.1054830

Accelerating the Translation of Nanomaterials in Biomedicine.
Mitragotri, S.; Anderson, D. G.; Chen, X.; Chow, E. K.; Ho, D.; Kabanov, A. V.; Karp, J. M.; Kataoka, K.; Mirkin, C. A.; Petrosko, S. H.; et al. ACS Nano 2015, 9 (7), 6644-6654. https://doi.org//10.1021/acsnano.5b03569

Synthesis and characterization of a self-fluorescent hyaluronic acid-based gel for dermal applications.
Menegatti, S.; Ruocco, N.; Kumar, S.; Zakrewsky, M.; Sanchez De Oliveira, J.; Helgeson, M. E.; Leal, G. L.; Mitragotri, S. Adv Healthc Mater 2015, 4 (15), 2297-2305. https://doi.org//10.1002/adhm.201500619

Peptides as skin penetration enhancers: mechanisms of action.
Kumar, S.; Zakrewsky, M.; Chen, M.; Menegatti, S.; Muraski, J. A.; Mitragotri, S. J Control Release 2015, 199, 168-178. https://doi.org//10.1016/j.jconrel.2014.12.006

Enhanced epidermal localization of topically applied steroids using SPACE peptide.
Kumar, S.; Chen, M.; Anselmo, A. C.; Muraski, J. A.; Mitragotri, S. Drug Deliv Transl Res 2015, 5 (5), 523-530. https://doi.org//10.1007/s13346-015-0232-4

Shape and size-dependent immune response to antigen-carrying nanoparticles.
Kumar, S.; Anselmo, A. C.; Banerjee, A.; Zakrewsky, M.; Mitragotri, S. J Control Release 2015, 220 (Pt A), 141-148. https://doi.org//10.1016/j.jconrel.2015.09.069

Topical delivery of Cyclosporine A into the skin using SPACE-peptide.
Chen, M.; Kumar, S.; Anselmo, A. C.; Gupta, V.; Slee, D. H.; Muraski, J. A.; Mitragotri, S. J Control Release 2015, 199, 190-197. https://doi.org//10.1016/j.jconrel.2014.11.015

Synergistic antitumor activity of camptothecin-doxorubicin combinations and their conjugates with hyaluronic acid.
Camacho, K. M.; Kumar, S.; Menegatti, S.; Vogus, D. R.; Anselmo, A. C.; Mitragotri, S. J Control Release 2015, 210, 198-207. https://doi.org//10.1016/j.jconrel.2015.04.031

Elasticity of nanoparticles influences their blood circulation, phagocytosis, endocytosis, and targeting.
Anselmo, A. C.; Zhang, M.; Kumar, S.; Vogus, D. R.; Menegatti, S.; Helgeson, M. E.; Mitragotri, S. ACS Nano 2015, 9 (3), 3169-3177. https://doi.org//10.1021/acsnano.5b00147

A Review of Clinical Translation of Inorganic Nanoparticles.
Anselmo, A. C.; Mitragotri, S. AAPS J 2015, 17 (5), 1041-1054. https://doi.org//10.1208/s12248-015-9780-2

Exploiting shape, cellular-hitchhiking and antibodies to target nanoparticles to lung endothelium: Synergy between physical, chemical and biological approaches.
Anselmo, A. C.; Kumar, S.; Gupta, V.; Pearce, A. M.; Ragusa, A.; Muzykantov, V.; Mitragotri, S. Biomaterials 2015, 68, 1-8. https://doi.org//10.1016/j.biomaterials.2015.07.043

Monocyte-mediated delivery of polymeric backpacks to inflamed tissues: a generalized strategy to deliver drugs to treat inflammation.
Anselmo, A. C.; Gilbert, J. B.; Kumar, S.; Gupta, V.; Cohen, R. E.; Rubner, M. F.; Mitragotri, S. J Control Release 2015, 199, 29-36. https://doi.org//10.1016/j.jconrel.2014.11.027

Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization.
Zakrewsky, M.; Lovejoy, K. S.; Kern, T. L.; Miller, T. E.; Le, V.; Nagy, A.; Goumas, A. M.; Iyer, R. S.; Del Sesto, R. E.; Koppisch, A. T.; et al.  Proc Natl Acad Sci U S A 2014, 111 (37), 13313-13318. https://doi.org//10.1073/pnas.1403995111

MoS(2) field-effect transistor for next-generation label-free biosensors.
Sarkar, D.; Liu, W.; Xie, X.; Anselmo, A. C.; Mitragotri, S.; Banerjee, K. ACS Nano 2014, 8 (4), 3992-4003. https://doi.org//10.1021/nn5009148

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies.
Mitragotri, S.; Burke, P. A.; Langer, R.  Nat Rev Drug Discov 2014, 13 (9), 655-672. https://doi.org//10.1038/nrd4363

Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm.
Howard, M.; Zern, B. J.; Anselmo, A. C.; Shuvaev, V. V.; Mitragotri, S.; Muzykantov, V. ACS Nano 2014, 8 (5), 4100-4132. https://doi.org//10.1021/nn500136z

Topical delivery of siRNA into skin using SPACE-peptide carriers.
Chen, M.; Zakrewsky, M.; Gupta, V.; Anselmo, A. C.; Slee, D. H.; Muraski, J. A.; Mitragotri, S. J Control Release 2014, 179, 33-41. https://doi.org//10.1016/j.jconrel.2014.01.006

Topical delivery of hyaluronic acid into skin using SPACE-peptide carriers.
Chen, M.; Gupta, V.; Anselmo, A. C.; Muraski, J. A.; Mitragotri, S. J Control Release 2014, 173, 67-74. https://doi.org//10.1016/j.jconrel.2013.10.007

Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects.
Barua, S.; Mitragotri, S.  Nano Today 2014, 9 (2), 223-243. https://doi.org//10.1016/j.nantod.2014.04.008

Platelet-like nanoparticles: mimicking shape, flexibility, and surface biology of platelets to target vascular injuries.
Anselmo, A. C.; Modery-Pawlowski, C. L.; Menegatti, S.; Kumar, S.; Vogus, D. R.; Tian, L. L.; Chen, M.; Squires, T. M.; Sen Gupta, A.; Mitragotri, S.  ACS Nano 2014, 8 (11), 11243-11253. https://doi.org//10.1021/nn503732m

An overview of clinical and commercial impact of drug delivery systems.
Anselmo, A. C.; Mitragotri, S. J Control Release 2014, 190, 15-28. https://doi.org//10.1016/j.jconrel.2014.03.053

Cell-mediated delivery of nanoparticles: taking advantage of circulatory cells to target nanoparticles.
Anselmo, A. C.; Mitragotri, S. J Control Release 2014, 190, 531-541. https://doi.org//10.1016/j.jconrel.2014.03.050

Synthesis of protein-based, rod-shaped particles from spherical templates using layer-by-layer assembly.
Zhou, Z.; Anselmo, A. C.; Mitragotri, S.  Adv Mater 2013, 25 (19), 2723-2727. https://doi.org//10.1002/adma.201300220

Diagnostic opportunities based on skin biomarkers.
Paliwal, S.; Hwang, B. H.; Tsai, K. Y.; Mitragotri, S.  Eur J Pharm Sci 2013, 50 (5), 546-556. https://doi.org//10.1016/j.ejps.2012.10.009

Approaches to synthetic platelet analogs.
Modery-Pawlowski, C. L.; Tian, L. L.; Pan, V.; McCrae, K. R.; Mitragotri, S.; Sen Gupta, A. Biomaterials 2013, 34 (2), 526-541. https://doi.org//10.1016/j.biomaterials.2012.09.074

Devices for overcoming biological barriers: the use of physical forces to disrupt the barriers.
Mitragotri, S. Adv Drug Deliv Rev 2013, 65 (1), 100-103. https://doi.org//10.1016/j.addr.2012.07.016

Engineering approaches to transdermal drug delivery: a tribute to contributions of prof. Robert Langer.
Mitragotri, S. Skin Pharmacol Physiol 2013, 26 (4-6), 263-276. https://doi.org//10.1159/000351947

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium.
Kolhar, P.; Anselmo, A. C.; Gupta, V.; Pant, K.; Prabhakarpandian, B.; Ruoslahti, E.; Mitragotri, S. Proc Natl Acad Sci U S A 2013, 110 (26), 10753-10758. https://doi.org//10.1073/pnas.1308345110

Optimized lysis buffer reagents for solubilization and preservation of proteins from cells and tissues.
Hwang, B. H.; Tsai, K. Y.; Mitragotri, S. Drug Deliv Transl Res 2013, 3 (5), 428-436. https://doi.org//10.1007/s13346-013-0128-0

Mucoadhesive intestinal devices for oral delivery of salmon calcitonin.
Gupta, V.; Hwang, B. H.; Lee, J.; Anselmo, A. C.; Doshi, N.; Mitragotri, S. J Control Release 2013, 172 (3), 753-762. https://doi.org//10.1016/j.jconrel.2013.09.004

A permeation enhancer for increasing transport of therapeutic macromolecules across the intestine.
Gupta, V.; Hwang, B. H.; Doshi, N.; Mitragotri, S. J Control Release 2013, 172 (2), 541-549. https://doi.org//10.1016/j.jconrel.2013.05.002

Permeation of insulin, calcitonin and exenatide across Caco-2 monolayers: measurement using a rapid, 3-day system.
Gupta, V.; Doshi, N.; Mitragotri, S. PLoS One 2013, 8 (2), e57136. https://doi.org//10.1371/journal.pone.0057136

Particle shape enhances specificity of antibody-displaying nanoparticles.
Barua, S.; Yoo, J. W.; Kolhar, P.; Wakankar, A.; Gokarn, Y. R.; Mitragotri, S. Proc Natl Acad Sci U S A 2013, 110 (9), 3270-3275. https://doi.org//10.1073/pnas.1216893110

Synergistic targeting of cell membrane, cytoplasm, and nucleus of cancer cells using rod-shaped nanoparticles.
Barua, S.; Mitragotri, S.  ACS Nano 2013, 7 (11), 9558-9570. https://doi.org//10.1021/nn403913k

Multifunctional nanoparticles for drug delivery and molecular imaging.
Bao, G.; Mitragotri, S.; Tong, S. Annu Rev Biomed Eng 2013, 15, 253-282. https://doi.org//10.1146/annurev-bioeng-071812-152409

Delivering nanoparticles to lungs while avoiding liver and spleen through adsorption on red blood cells.
Anselmo, A. C.; Gupta, V.; Zern, B. J.; Pan, D.; Zakrewsky, M.; Muzykantov, V.; Mitragotri, S. ACS Nano 2013, 7 (12), 11129-11137. https://doi.org//10.1021/nn404853z

Glycosylation facilitates transdermal transport of macromolecules.
Pino, C. J.; Gutterman, J. U.; Vonwil, D.; Mitragotri, S.; Shastri, V. P.  Proc Natl Acad Sci U S A 2012, 109 (52), 21283-21288. https://doi.org//10.1073/pnas.1200942109

Endocytic pathway rapidly delivers internalized molecules to lysosomes: an analysis of vesicle trafficking, clustering and mass transfer.
Pangarkar, C.; Dinh, A. T.; Mitragotri, S. J Control Release 2012, 162 (1), 76-83. https://doi.org//10.1016/j.jconrel.2012.05.022

Sampling of disease biomarkers from skin for theranostic applications.
Ogura, M.; Paliwal, S.; Mitragotri, S.  Drug Deliv Transl Res 2012, 2 (2), 87-94. https://doi.org//10.1007/s13346-012-0061-7

Materials for drug delivery: innovative solutions to address complex biological hurdles.
Mitragotri, S.; Lahann, J.  Adv Mater 2012, 24 (28), 3717-3723. https://doi.org//10.1002/adma.201202080

Spontaneous shape reconfigurations in multicompartmental microcylinders.
Lee, K. J.; Yoon, J.; Rahmani, S.; Hwang, S.; Bhaskar, S.; Mitragotri, S.; Lahann, J.  Proc Natl Acad Sci U S A 2012, 109 (40), 16057-16062. https://doi.org//10.1073/pnas.1213669109

Mucociliary clearance of micro- and nanoparticles is independent of size, shape and charge--an ex vivo and in silico approach.
Kirch, J.; Guenther, M.; Doshi, N.; Schaefer, U. F.; Schneider, M.; Mitragotri, S.; Lehr, C. M.  J Control Release 2012, 159 (1), 128-134. https://doi.org//10.1016/j.jconrel.2011.12.015

Delivery systems for intradermal vaccination.
Kim, Y. C.; Jarrahian, C.; Zehrung, D.; Mitragotri, S.; Prausnitz, M. R. Curr Top Microbiol Immunol 2012, 351, 77-112. https://doi.org//10.1007/82_2011_123

A reagent to facilitate protein recovery from cells and tissues.
Hwang, B. H.; Doshi, N.; Tsai, K. Y.; Mitragotri, S.  Drug Deliv Transl Res 2012, 2 (5), 297-304. https://doi.org//10.1007/s13346-012-0071-5

Platelet mimetic particles for targeting thrombi in flowing blood.
Doshi, N.; Orje, J. N.; Molins, B.; Smith, J. W.; Mitragotri, S.; Ruggeri, Z. M. Adv Mater 2012, 24 (28), 3864-3869. https://doi.org//10.1002/adma.201200607

Bio-inspired, bioengineered and biomimetic drug delivery carriers.
Yoo, J. W.; Irvine, D. J.; Discher, D. E.; Mitragotri, S. Nat Rev Drug Discov 2011, 10 (7), 521-535. https://doi.org//10.1038/nrd3499

Adaptive micro and nanoparticles: temporal control over carrier properties to facilitate drug delivery.
Yoo, J. W.; Doshi, N.; Mitragotri, S. Adv Drug Deliv Rev 2011, 63 (14-15), 1247-1256. https://doi.org//10.1016/j.addr.2011.05.004

Designing micro- and nano-particles for treating rheumatoid arthritis.
Mitragotri, S.; Yoo, J. W. Arch Pharm Res 2011, 34 (11), 1887-1897. https://doi.org//10.1007/s12272-011-1109-9

Mathematical models of skin permeability: an overview.
Mitragotri, S.; Anissimov, Y. G.; Bunge, A. L.; Frasch, H. F.; Guy, R. H.; Hadgraft, J.; Kasting, G. B.; Lane, M. E.; Roberts, M. S. Int J Pharm 2011, 418 (1), 115-129. https://doi.org//10.1016/j.ijpharm.2011.02.023

Delivery of polymeric particles into skin using needle-free liquid jet injectors.
Michinaka, Y.; Mitragotri, S. J Control Release 2011, 153 (3), 249-254. https://doi.org//10.1016/j.jconrel.2011.03.024

Polymer nanoneedle-mediated intracellular drug delivery.
Kolhar, P.; Doshi, N.; Mitragotri, S. Small 2011, 7 (14), 2094-2100. https://doi.org//10.1002/smll.201100497

Effect of surfactant mixtures on skin structure and barrier properties.
James-Smith, M. A.; Hellner, B.; Annunziato, N.; Mitragotri, S. Ann Biomed Eng 2011, 39 (4), 1215-1223. https://doi.org//10.1007/s10439-010-0190-4

Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer.
Hsu, T.; Mitragotri, S. Proc Natl Acad Sci U S A 2011, 108 (38), 15816-15821. https://doi.org//10.1073/pnas.1016152108

Cell-based drug delivery devices using phagocytosis-resistant backpacks.
Doshi, N.; Swiston, A. J.; Gilbert, J. B.; Alcaraz, M. L.; Cohen, R. E.; Rubner, M. F.; Mitragotri, S. Adv Mater 2011, 23 (12), H105-109. https://doi.org//10.1002/adma.201004074

Polymer particles that switch shape in response to a stimulus.
Yoo, J. W.; Mitragotri, S. Proc Natl Acad Sci U S A 2010, 107 (25), 11205-11210. https://doi.org//10.1073/pnas.1000346107

Endocytosis and Intracellular Distribution of PLGA Particles in Endothelial Cells: Effect of Particle Geometry.
Yoo, J. W.; Doshi, N.; Mitragotri, S. Macromol Rapid Commun 2010, 31 (2), 142-148. https://doi.org//10.1002/marc.200900592

Factors that control the circulation time of nanoparticles in blood: challenges, solutions and future prospects.
Yoo, J. W.; Chambers, E.; Mitragotri, S. Curr Pharm Des 2010, 16 (21), 2298-2307. https://doi.org//10.2174/138161210791920496

Polymer particle shape independently influences binding and internalization by macrophages.
Sharma, G.; Valenta, D. T.; Altman, Y.; Harvey, S.; Xie, H.; Mitragotri, S.; Smith, J. W. J Control Release 2010, 147 (3), 408-412. https://doi.org//10.1016/j.jconrel.2010.07.116

Rapid sampling of molecules via skin for diagnostic and forensic applications.
Paliwal, S.; Ogura, M.; Mitragotri, S. Pharm Res 2010, 27 (7), 1255-1263. https://doi.org//10.1007/s11095-010-0081-2

One-step acquisition of functional biomolecules from tissues.
Paliwal, S.; Ogura, M.; Mitragotri, S. Proc Natl Acad Sci U S A 2010, 107 (33), 14627-14632. https://doi.org//10.1073/pnas.1004302107

Ultrasound-enhanced drug transport and distribution in the brain.
Liu, Y.; Paliwal, S.; Bankiewicz, K. S.; Bringas, J. R.; Heart, G.; Mitragotri, S.; Prausnitz, M. R. AAPS PharmSciTech 2010, 11 (3), 1005-1017. https://doi.org//10.1208/s12249-010-9458-0

Transcutaneous immunization: an overview of advantages, disease targets, vaccines, and delivery technologies.
Karande, P.; Mitragotri, S. Annu Rev Chem Biomol Eng 2010, 1, 175-201. https://doi.org//10.1146/annurev-chembioeng-073009-100948

Flow and adhesion of drug carriers in blood vessels depend on their shape: a study using model synthetic microvascular networks.
Doshi, N.; Prabhakarpandian, B.; Rea-Ramsey, A.; Pant, K.; Sundaram, S.; Mitragotri, S. J Control Release 2010, 146 (2), 196-200. https://doi.org//10.1016/j.jconrel.2010.04.007

Macrophages recognize size and shape of their targets.
Doshi, N.; Mitragotri, S. PLoS One 2010, 5 (4), e10051. https://doi.org//10.1371/journal.pone.0010051

Needle-shaped polymeric particles induce transient disruption of cell membranes.
Doshi, N.; Mitragotri, S. J R Soc Interface 2010, 7 Suppl 4, S403-410. https://doi.org//10.1098/rsif.2010.0134.focus

Novel topical microbicides through combinatorial strategies.
Arora, A.; Mitragotri, S. Pharm Res 2010, 27 (7), 1264-1272. https://doi.org//10.1007/s11095-010-0095-9

Multicomponent chemical enhancer formulations for transdermal drug delivery: more is not always better.
Arora, A.; Kisak, E.; Karande, P.; Newsam, J.; Mitragotri, S. J Control Release 2010, 144 (2), 175-180. https://doi.org//10.1016/j.jconrel.2010.02.015

Dynamic control of needle-free jet injection.
Stachowiak, J. C.; Li, T. H.; Arora, A.; Mitragotri, S.; Fletcher, D. A. J Control Release 2009, 135 (2), 104-112. https://doi.org//10.1016/j.jconrel.2009.01.003

Physical approaches to biomaterial design.
Mitragotri, S.; Lahann, J. Nat Mater 2009, 8 (1), 15-23. https://doi.org//10.1038/nmat2344

In drug delivery, shape does matter.
Mitragotri, S. Pharm Res 2009, 26 (1), 232-234. https://doi.org//10.1007/s11095-008-9740-y

Enhancement of transdermal drug delivery via synergistic action of chemicals.
Karande, P.; Mitragotri, S. Biochim Biophys Acta 2009, 1788 (11), 2362-2373. https://doi.org//10.1016/j.bbamem.2009.08.015

Transcutaneous immunization using common chemicals.
Karande, P.; Arora, A.; Pham, T. K.; Stevens, D.; Wojicki, A.; Mitragotri, S. J Control Release 2009, 138 (2), 134-140. https://doi.org//10.1016/j.jconrel.2009.05.003

Red blood cell-mimicking synthetic biomaterial particles.
Doshi, N.; Zahr, A. S.; Bhaskar, S.; Lahann, J.; Mitragotri, S. Proc Natl Acad Sci U S A 2009, 106 (51), 21495-21499. https://doi.org//10.1073/pnas.0907127106

Shape induced inhibition of phagocytosis of polymer particles.
Champion, J. A.; Mitragotri, S. Pharm Res 2009, 26 (1), 244-249. https://doi.org//10.1007/s11095-008-9626-z

Mechanistic analysis of chemical permeation enhancers for oral drug delivery.
Whitehead, K.; Mitragotri, S. Pharm Res 2008, 25 (6), 1412-1419. https://doi.org//10.1007/s11095-008-9542-2

Safe and effective permeation enhancers for oral drug delivery.
Whitehead, K.; Karr, N.; Mitragotri, S. Pharm Res 2008, 25 (8), 1782-1788. https://doi.org//10.1007/s11095-007-9488-9

Discovery of synergistic permeation enhancers for oral drug delivery.
Whitehead, K.; Karr, N.; Mitragotri, S. J Control Release 2008, 128 (2), 128-133. https://doi.org//10.1016/j.jconrel.2008.03.005

Therapeutic opportunities in biological responses of ultrasound.
Paliwal, S.; Mitragotri, S. Ultrasonics 2008, 48 (4), 271-278. https://doi.org//10.1016/j.ultras.2008.02.002

Low-frequency sonophoresis: current status and future prospects.
Ogura, M.; Paliwal, S.; Mitragotri, S. Adv Drug Deliv Rev 2008, 60 (10), 1218-1223. https://doi.org//10.1016/j.addr.2008.03.006

Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers.
Muro, S.; Garnacho, C.; Champion, J. A.; Leferovich, J.; Gajewski, C.; Schuchman, E. H.; Mitragotri, S.; Muzykantov, V. R. Mol Ther 2008, 16 (8), 1450-1458. https://doi.org//10.1038/mt.2008.127

Role of particle size in phagocytosis of polymeric microspheres.
Champion, J. A.; Walker, A.; Mitragotri, S. Pharm Res 2008, 25 (8), 1815-1821. https://doi.org//10.1007/s11095-008-9562-y

Micro-scale devices for transdermal drug delivery.
Arora, A.; Prausnitz, M. R.; Mitragotri, S. Int J Pharm 2008, 364 (2), 227-236. https://doi.org//10.1016/j.ijpharm.2008.08.032

Temperature dependence of skin permeability to hydrophilic and hydrophobic solutes.
Mitragotri, S. J Pharm Sci 2007, 96 (7), 1832-1839. https://doi.org//10.1002/jps.20793

Synergistic effects of chemical enhancers on skin permeability: a case study of sodium lauroylsarcosinate and sorbitan monolaurate.
Karande, P.; Jain, A.; Arora, A.; Ho, M. J.; Mitragotri, S. Eur J Pharm Sci 2007, 31 (1), 1-7. https://doi.org//10.1016/j.ejps.2007.01.004

Identification of peptide ligands facilitating nanoparticle attachment to erythrocytes.
Hall, S. S.; Mitragotri, S.; Daugherty, P. S. Biotechnol Prog 2007, 23 (3), 749-754. https://doi.org//10.1021/bp060333l

Modeling of pattern regulation in melanophores.
Dinh, A. T.; Theofanous, T.; Mitragotri, S. J Theor Biol 2007, 244 (1), 141-153. https://doi.org//10.1016/j.jtbi.2006.07.024

Understanding intracellular transport processes pertinent to synthetic gene delivery via stochastic simulations and sensitivity analyses.
Dinh, A. T.; Pangarkar, C.; Theofanous, T.; Mitragotri, S. Biophys J 2007, 92 (3), 831-846. https://doi.org//10.1529/biophysj.106.095521

Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers.
Champion, J. A.; Katare, Y. K.; Mitragotri, S. J Control Release 2007, 121 (1-2), 3-9. https://doi.org//10.1016/j.jconrel.2007.03.022

Making polymeric micro- and nanoparticles of complex shapes.
Champion, J. A.; Katare, Y. K.; Mitragotri, S. Proc Natl Acad Sci U S A 2007, 104 (29), 11901-11904. https://doi.org//10.1073/pnas.0705326104

Long circulating nanoparticles via adhesion on red blood cells: mechanism and extended circulation.
Chambers, E.; Mitragotri, S. Exp Biol Med (Maywood) 2007, 232 (7), 958-966.

Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets.
Arora, A.; Hakim, I.; Baxter, J.; Rathnasingham, R.; Srinivasan, R.; Fletcher, D. A.; Mitragotri, S. Proc Natl Acad Sci U S A 2007, 104 (11), 4255-4260. https://doi.org//10.1073/pnas.0700182104

Ultrasound-induced cavitation: applications in drug and gene delivery.
Paliwal, S.; Mitragotri, S. Expert Opin Drug Deliv 2006, 3 (6), 713-726. https://doi.org//10.1517/17425247.3.6.713

Low-frequency sonophoresis: ultrastructural basis for stratum corneum permeability assessed using quantum dots.
Paliwal, S.; Menon, G. K.; Mitragotri, S. J Invest Dermatol 2006, 126 (5), 1095-1101. https://doi.org//10.1038/sj.jid.5700248

Current status and future prospects of needle-free liquid jet injectors.
Mitragotri, S. Nat Rev Drug Discov 2006, 5 (7), 543-548. https://doi.org//10.1038/nrd2076

Evaluation of chemical enhancers in the transdermal delivery of lidocaine.
Lee, P. J.; Ahmad, N.; Langer, R.; Mitragotri, S.; Prasad Shastri, V. Int J Pharm 2006, 308 (1-2), 33-39. https://doi.org//10.1016/j.ijpharm.2005.10.027

Relationships between skin's electrical impedance and permeability in the presence of chemical enhancers.
Karande, P.; Jain, A.; Mitragotri, S. J Control Release 2006, 110 (2), 307-313. https://doi.org//10.1016/j.jconrel.2005.10.012

Insights into synergistic interactions in binary mixtures of chemical permeation enhancers for transdermal drug delivery.
Karande, P.; Jain, A.; Mitragotri, S. J Control Release 2006, 115 (1), 85-93. https://doi.org//10.1016/j.jconrel.2006.07.001

Theory of spatial patterns of intracellular organelles.
Dinh, A. T.; Pangarkar, C.; Theofanous, T.; Mitragotri, S. Biophys J 2006, 90 (10), L67-69. https://doi.org//10.1529/biophysj.106.082875

Role of target geometry in phagocytosis.
Champion, J. A.; Mitragotri, S. Proc Natl Acad Sci U S A 2006, 103 (13), 4930-4934. https://doi.org//10.1073/pnas.0600997103

Needle-free liquid jet injections: mechanisms and applications.
Baxter, J.; Mitragotri, S. Expert Rev Med Devices 2006, 3 (5), 565-574. https://doi.org//10.1586/17434440.3.5.565

Low-frequency ultrasound as a transcutaneous immunization adjuvant.
Tezel, A.; Paliwal, S.; Shen, Z.; Mitragotri, S. Vaccine 2005, 23 (29), 3800-3807. https://doi.org//10.1016/j.vaccine.2005.02.027

Dynamics and spatial organization of endosomes in mammalian cells.
Pangarkar, C.; Dinh, A. T.; Mitragotri, S. Phys Rev Lett 2005, 95 (15), 158101. https://doi.org//10.1103/PhysRevLett.95.158101

Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound.
Paliwal, S.; Sundaram, J.; Mitragotri, S. Br J Cancer 2005, 92 (3), 499-502. https://doi.org//10.1038/sj.bjc.6602364

Healing sound: the use of ultrasound in drug delivery and other therapeutic applications.
Mitragotri, S. Nat Rev Drug Discov 2005, 4 (3), 255-260. https://doi.org//10.1038/nrd1662

Immunization without needles.
Mitragotri, S. Nat Rev Immunol 2005, 5 (12), 905-916. https://doi.org//10.1038/nri1728

Design principles of chemical penetration enhancers for transdermal drug delivery.
Karande, P.; Jain, A.; Ergun, K.; Kispersky, V.; Mitragotri, S. Proc Natl Acad Sci U S A 2005, 102 (13), 4688-4693. https://doi.org//10.1073/pnas.0501176102

A model for intracellular trafficking of adenoviral vectors.
Dinh, A. T.; Theofanous, T.; Mitragotri, S. Biophys J 2005, 89 (3), 1574-1588. https://doi.org//10.1529/biophysj.105.059477

Jet-induced skin puncture and its impact on needle-free jet injections: experimental studies and a predictive model.
Baxter, J.; Mitragotri, S. J Control Release 2005, 106 (3), 361-373. https://doi.org//10.1016/j.jconrel.2005.05.023

Oral delivery of macromolecules using intestinal patches: applications for insulin delivery.
Whitehead, K.; Shen, Z.; Mitragotri, S. J Control Release 2004, 98 (1), 37-45. https://doi.org//10.1016/j.jconrel.2004.04.013

Topical delivery of anti-sense oligonucleotides using low-frequency sonophoresis.
Tezel, A.; Dokka, S.; Kelly, S.; Hardee, G. E.; Mitragotri, S. Pharm Res 2004, 21 (12), 2219-2225. https://doi.org//10.1007/s11095-004-7674-6

Investigations of needle-free jet injections.
Schramm-Baxter, J. R.; Mitragotri, S. Conf Proc IEEE Eng Med Biol Soc 2004, 2004, 3543-3546. https://doi.org//10.1109/IEMBS.2004.1403996

Needle-free jet injections: dependence of jet penetration and dispersion in the skin on jet power.
Schramm-Baxter, J.; Mitragotri, S. J Control Release 2004, 97 (3), 527-535. https://doi.org//10.1016/j.jconrel.2004.04.006

Jet injection into polyacrylamide gels: investigation of jet injection mechanics.
Schramm-Baxter, J.; Katrencik, J.; Mitragotri, S. J Biomech 2004, 37 (8), 1181-1188. https://doi.org//10.1016/j.jbiomech.2003.12.006

Current status and future potential of transdermal drug delivery.
Prausnitz, M. R.; Mitragotri, S.; Langer, R. Nat Rev Drug Discov 2004, 3 (2), 115-124. https://doi.org//10.1038/nrd1304

Low-frequency sonophoresis: a review.
Mitragotri, S.; Kost, J. Adv Drug Deliv Rev 2004, 56 (5), 589-601. https://doi.org//10.1016/j.addr.2003.10.024

Breaking the skin barrier.
Mitragotri, S. Adv Drug Deliv Rev 2004, 56 (5), 555-556. https://doi.org//10.1016/j.addr.2003.10.022

Sonophoresis: a 50-year journey.
Mitragotri, S. Drug Discov Today 2004, 9 (17), 735-736. https://doi.org//10.1016/S1359-6446(04)03209-X

Discovery of transdermal penetration enhancers by high-throughput screening.
Karande, P.; Jain, A.; Mitragotri, S. Nat Biotechnol 2004, 22 (2), 192-197. https://doi.org//10.1038/nbt928

Prolonged circulation of large polymeric nanoparticles by non-covalent adsorption on erythrocytes.
Chambers, E.; Mitragotri, S. J Control Release 2004, 100 (1), 111-119. https://doi.org//10.1016/j.jconrel.2004.08.005

Description of transdermal transport of hydrophilic solutes during low-frequency sonophoresis based on a modified porous pathway model.
Tezel, A.; Sens, A.; Mitragotri, S. J Pharm Sci 2003, 92 (2), 381-393. https://doi.org//10.1002/jps.10299

On the origin of size-dependent tortuosity for permeation of hydrophilic solutes across the stratum corneum.
Tezel, A.; Mitragotri, S. J Control Release 2003, 86 (1), 183-186. https://doi.org//10.1016/s0168-3659(02)00375-9

Interactions of inertial cavitation bubbles with stratum corneum lipid bilayers during low-frequency sonophoresis.
Tezel, A.; Mitragotri, S. Biophys J 2003, 85 (6), 3502-3512. https://doi.org//10.1016/S0006-3495(03)74770-5

An experimental and theoretical analysis of ultrasound-induced permeabilization of cell membranes.
Sundaram, J.; Mellein, B. R.; Mitragotri, S. Biophys J 2003, 84 (5), 3087-3101. https://doi.org//10.1016/S0006-3495(03)70034-4

Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways.
Mitragotri, S. J Control Release 2003, 86 (1), 69-92. https://doi.org//10.1016/s0168-3659(02)00321-8

A reversibly switching surface.
Lahann, J.; Mitragotri, S.; Tran, T. N.; Kaido, H.; Sundaram, J.; Choi, I. S.; Hoffer, S.; Somorjai, G. A.; Langer, R. Science 2003, 299 (5605), 371-374. https://doi.org//10.1126/science.1078933

Dependence of skin permeability on contact area.
Karande, P.; Mitragotri, S. Pharm Res 2003, 20 (2), 257-263. https://doi.org//10.1023/a:1022231406277

Synergistic effect of low-frequency ultrasound and surfactants on skin permeability.
Tezel, A.; Sens, A.; Tuchscherer, J.; Mitragotri, S. J Pharm Sci 2002, 91 (1), 91-100. https://doi.org//10.1002/jps.10000

Investigations of the role of cavitation in low-frequency sonophoresis using acoustic spectroscopy.
Tezel, A.; Sens, A.; Mitragotri, S. J Pharm Sci 2002, 91 (2), 444-453. https://doi.org//10.1002/jps.10024

Incorporation of lipophilic pathways into the porous pathway model for describing skin permeabilization during low-frequency sonophoresis.
Tezel, A.; Sens, A.; Mitragotri, S. J Control Release 2002, 83 (1), 183-188. https://doi.org//10.1016/s0168-3659(02)00177-3

A theoretical analysis of low-frequency sonophoresis: dependence of transdermal transport pathways on frequency and energy density.
Tezel, A.; Sens, A.; Mitragotri, S. Pharm Res 2002, 19 (12), 1841-1846. https://doi.org//10.1023/a:1021493424737

Porous resins as a cavitation enhancer for low-frequency sonophoresis.
Terahara, T.; Mitragotri, S.; Langer, R. J Pharm Sci 2002, 91 (3), 753-759. https://doi.org//10.1002/jps.10080

Dependence of low-frequency sonophoresis on ultrasound parameters; distance of the horn and intensity.
Terahara, T.; Mitragotri, S.; Kost, J.; Langer, R. Int J Pharm 2002, 235 (1-2), 35-42. https://doi.org//10.1016/s0378-5173(01)00981-4

Intestinal patches for oral drug delivery.
Shen, Z.; Mitragotri, S. Pharm Res 2002, 19 (4), 391-395. https://doi.org//10.1023/a:1015118923204

Transdermal drug delivery by jet injectors: energetics of jet formation and penetration.
Schramm, J.; Mitragotri, S. Pharm Res 2002, 19 (11), 1673-1679. https://doi.org//10.1023/a:1020753329492

A theoretical analysis of permeation of small hydrophobic solutes across the stratum corneum based on Scaled Particle Theory.
Mitragotri, S. J Pharm Sci 2002, 91 (3), 744-752. https://doi.org//10.1002/jps.10048

High throughput screening of transdermal formulations.
Karande, P.; Mitragotri, S. Pharm Res 2002, 19 (5), 655-660. https://doi.org//10.1023/a:1015362230726

Frequency dependence of sonophoresis.
Tezel, A.; Sens, A.; Tuchscherer, J.; Mitragotri, S. Pharm Res 2001, 18 (12), 1694-1700. https://doi.org//10.1023/a:1013366328457

Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis.
Tang, H.; Mitragotri, S.; Blankschtein, D.; Langer, R. J Pharm Sci 2001, 90 (5), 545-568. https://doi.org//10.1002/1520-6017(200105)90:5<545::aid-jps1012>3.0.co;2-h

Transdermal delivery of heparin and low-molecular weight heparin using low-frequency ultrasound.
Mitragotri, S.; Kost, J. Pharm Res 2001, 18 (8), 1151-1156. https://doi.org//10.1023/a:1010979010907

Effect of therapeutic ultrasound on partition and diffusion coefficients in human stratum corneum.
Mitragotri, S. J Control Release 2001, 71 (1), 23-29. https://doi.org//10.1016/s0168-3659(00)00344-8

Effect of bilayer distruption on transdermal transport of low-molecular weight hydrophobic solutes.
Mitragotri, S. Pharm Res 2001, 18 (7), 1018-1023. https://doi.org//10.1023/a:1010952731205

Synergistic effect of low-frequency ultrasound and sodium lauryl sulfate on transdermal transport.
Mitragotri, S.; Ray, D.; Farrell, J.; Tang, H.; Yu, B.; Kost, J.; Blankschtein, D.; Langer, R. J Pharm Sci 2000, 89 (7), 892-900. https://doi.org//10.1002/1520-6017(200007)89:7<892::AID-JPS6>3.0.CO;2-V

Low-frequency sonophoresis: a noninvasive method of drug delivery and diagnostics.
Mitragotri, S.; Kost, J. Biotechnol Prog 2000, 16 (3), 488-492. https://doi.org//10.1021/bp000024+

Determination of threshold energy dose for ultrasound-induced transdermal drug transport.
Mitragotri, S.; Farrell, J.; Tang, H.; Terahara, T.; Kost, J.; Langer, R. J Control Release 2000, 63 (1-2), 41-52. https://doi.org//10.1016/s0168-3659(99)00178-9

Transdermal extraction of analytes using low-frequency ultrasound.
Mitragotri, S.; Coleman, M.; Kost, J.; Langer, R. Pharm Res 2000, 17 (4), 466-470. https://doi.org//10.1023/a:1007537222591

Analysis of ultrasonically extracted interstitial fluid as a predictor of blood glucose levels.
Mitragotri, S.; Coleman, M.; Kost, J.; Langer, R. J Appl Physiol (1985) 2000, 89 (3), 961-966. https://doi.org//10.1152/jappl.2000.89.3.961

In situ determination of partition and diffusion coefficients in the lipid bilayers of stratum corneum.
Mitragotri, S. Pharm Res 2000, 17 (8), 1026-1029. https://doi.org//10.1023/a:1007547809430

Synergistic effect of enhancers for transdermal drug delivery.
Mitragotri, S. Pharm Res 2000, 17 (11), 1354-1359. https://doi.org//10.1023/a:1007522114438

Combined effect of low-frequency ultrasound and iontophoresis: applications for transdermal heparin delivery.
Le, L.; Kost, J.; Mitragotri, S. Pharm Res 2000, 17 (9), 1151-1154. https://doi.org//10.1023/a:1026426317413

Transdermal monitoring of glucose and other analytes using ultrasound.
Kost, J.; Mitragotri, S.; Gabbay, R. A.; Pishko, M.; Langer, R. Nat Med 2000, 6 (3), 347-350. https://doi.org//10.1038/73213

An analysis of the size selectivity of solute partitioning, diffusion, and permeation across lipid bilayers.
Mitragotri, S.; Johnson, M. E.; Blankschtein, D.; Langer, R. Biophys J 1999, 77 (3), 1268-1283. https://doi.org//10.1016/S0006-3495(99)76978-X

An explanation for the variation of the sonophoretic transdermal transport enhancement from drug to drug.
Mitragotri, S.; Blankschtein, D.; Langer, R. J Pharm Sci 1997, 86 (10), 1190-1192. https://doi.org//10.1021/js960528v

Transdermal drug delivery using low-frequency sonophoresis.
Mitragotri, S.; Blankschtein, D.; Langer, R. Pharm Res 1996, 13 (3), 411-420. https://doi.org//10.1023/a:1016096626810

Synergistic effect of electric field and ultrasound on transdermal transport.
Kost, J.; Pliquett, U.; Mitragotri, S.; Yamamoto, A.; Langer, R.; Weaver, J. Pharm Res 1996, 13 (4), 633-638. https://doi.org//10.1023/a:1016070710397

Synergistic effects of chemical enhancers and therapeutic ultrasound on transdermal drug delivery.
Johnson, M. E.; Mitragotri, S.; Patel, A.; Blankschtein, D.; Langer, R. J Pharm Sci 1996, 85 (7), 670-679. https://doi.org//10.1021/js960079z

A mechanistic study of ultrasonically-enhanced transdermal drug delivery.
Mitragotri, S.; Edwards, D. A.; Blankschtein, D.; Langer, R. J Pharm Sci 1995, 84 (6), 697-706. https://doi.org//10.1002/jps.2600840607

Ultrasound-mediated transdermal protein delivery.
Mitragotri, S.; Blankschtein, D.; Langer, R. Science 1995, 269 (5225), 850-853. https://doi.org//10.1126/science.7638603